Today I did a little reading about the biology of obesity. Some key players are leptin which makes you feel full and ghrelin which makes you want to eat more. Then there were an awful lot of other hormones that I had never heard of before. It's interesting because fat cells (adipocytes) are essentially seen as endocrine cells which release all these other things I have never heard of like:
-Factor D/Adiposin which is a complement factor
- Adiponectin which is decreased in obesity and works to increase insulin sensitibity and lipid oxidation
-Resistan - which is increased in obesity
- RBP4 - which is also increased in obesity
- alpha-MSH which is what is stimulated by leptin that inhibits apetite in the hypothalmus and acts as a precursor to POMC
- AgRP (Agouti related peptide) which is overexpressed in obesity and acts to antagonize the MC4 receptor for alpha-MSH
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Dr. Oz was on Oprah today and talked about sleep terror, sleepeating, etc. The sleep expert mentioned that there are medical treatments for these disorder, but he didn't mention exactly what they are. I am curious....
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